Admixture Dynamics, Natural Selection and Diseases in by Wenfei Jin

By Wenfei Jin

In this thesis, Dr. Jin offers the distribution of ancestral chromosomal segments within the admixed genome, which may give you the info had to discover inhabitants admixture dynamics. the writer derives actual inhabitants histories of African americans and Mexicans utilizing genome-wide unmarried nucleotide polymorphisms (SNPs) info. Mapping the genetic history allows the learn of common choice within the admixed inhabitants, and the writer identifies the signs of choice in African americans given that their African ancestors left for the US. He extra demonstrates that the various choice signs have been linked to African American-specific high-risk illnesses comparable to prostate melanoma and high blood pressure, suggesting a major position those disease-related genes may need performed in adapting to their new setting. finally, the writer finds the complexity of average choice in shaping human susceptibility to illness. The thesis considerably advances our realizing of the hot inhabitants admixture, edition to neighborhood atmosphere and its well-being implications.

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Sabeti PC, et al. Positive natural selection in the human lineage. Science. 2006;312:1614–20. Novembre J, Di Rienzo A. Spatial patterns of variation due to natural selection in humans. Nat Rev Genet. 2009;10:745–55. Pritchard JK, Pickrell JK, Coop G. The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. Curr Biol. 2010;20:R208–15. Jablonski NG, Chaplin G. Human skin pigmentation as an adaptation to UV radiation. Proc Natl Acad Sci USA. 2010;107:8962–8. Harding RM, et al.

Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping. Eur J Hum Genet. 2014;22:930–7. Chapter 3 Exploring Population Admixture Dynamics via Distribution of LACS Abstract By comparing the distribution of LACS in admixed population with those of various hypothesized scenarios, we could find the scenario with distribution of LACS best fit the observed distribution. Based on 491,526 autosomal SNPs genotyped in thousands of African Americans, we found that a continuous gene flow model, in which African Americans continuously received gene flow from European parental population over about 14 generations, best explained the admixture dynamics of African Americans among several putative scenarios.

4 Signatures of association in admixture mapping in HI and GA models. Vertical dashed green line represents the susceptibility locus. Heretical dashed black line represents the theoretical mean of genetic contribution of the given parental population. Reprint from Jin et al. [24] Therefore, the p-value of susceptibility locus in GA model could be the same as that in HI because the highest ancestral deviations in both HI and GA models were identical. In contrast, the p-values in case-only designed admixture mapping were calculated based on the empirical distribution of LACS in cases [9, 23].

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